Simplification From Tenofovir Plus Lamivudine or Emtricitabine Plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir Plus Lamivudine in Virologically-Suppressed-HIVInfected Adults With Osteopenia
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Judit Pich
With
Fundacion Clinic per a la Recerca Biomédica
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Human immunodeficiency virus-1-infected subjects with age ≥18 years old
Hip or spine T-scores between \< -1.0 and \>-2.5 by dual-energy X-ray absorptiometry (in the previous 24 weeks)
Stable antiretroviral treatment based on tenofovir and lamivudine or emtricitabine and boosted protease inhibitor for at least 24 weeks.
Having plasma human immunodeficiency virus-1 RNA \<50 copies/mL for at least the previous 24 weeks, including at least two samples.
You may not be if
Pregnancy, breast-feeding status or plans for pregnancy in the short term
Primary genotypic resistance mutations and/or previous virological failures to atazanavir or lamivudine/emtricitabine
Chronic hepatitis B infection
Patients with indication for therapy for the prevention of bone fractures
25-OH vitamin D deficiency (\< 10ng/mL)
Hypogonadism (low total testosterone according to local reference range)
Hypothyroidism (low T4 and increased thyroid stimulating hormone levels according to local reference ranges)
Hyperparathyroidism (increased parathyroid hormone level with hypercalcaemia according to local reference ranges)
Having received oral corticosteroids or inhaled fluticasone (daily doses higher than 5 mg/d prednisone equivalent for 3 months or more)
Using anti-resorptive therapy (Calcium and vitamin D supplements are encouraged but not mandated)
Body mass index lower than 19
Clareo Health | Simplification From Tenofovir Plus Lamivudine or Emtricitabine Plus Ritonavir-Boosted-Protease Inhibitor to Ritonavir-Boosted-Atazanavir Plus Lamivudine in Virologically-Suppressed-HIVInfected Adults With Osteopenia
