Treatment with corticosteroids or disease-modifying therapies (interferon beta, glatiramer acetate, natalizumab, fingolimod, teriflunomide) within 30 days of the first baseline MRI scan.
Treatment at any time with mitoxantrone, cyclophosphamide, or any other long acting immunosuppressant
Prior treatment of greater than 1 month at any time with DMF
