Use of medication for bipolar depression or other psychotropic drugs

Current Axis I mental disorders other than bipolar depression based on structured clinical interview

Current borderline or antisocial personality disorder based on structured clinical interview

Major medical or neurological illnesses (epilepsy, multiple sclerosis, brain tumor, cerebrovascular disease, etc)

Hypersensitivity to divalproate or valpromide

Diagnosis of porphyria

Current or past liver diseases

Severe dysfunction in liver or pancreas

Use of mefloquine

Alcohol or substance abuse/dependence

Intelligence quotient of 80 or below

Contraindications to magnetic resonance imaging

Pregnancy or breastfeeding

Allergy or intolerance to the study drugs

Combined Cytidine and Creatine-containing Drug in the Treatment of the Bipolar Depression