Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Bayer
With
ImmunoGen and MorphoSys
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Histological documentation of malignant pleural mesothelioma (MPM) overexpressing mesothelin
Unresectable locally advanced or metastatic MPM after locally confirmed progression on 1st line treatment with platinum in combination with pemetrexed.
Patients must have measurable disease
Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
Life expectancy of at least 3 months.
Adequate bone marrow, liver and renal function
Left ventricular ejection fraction (LVEF) ≥ 50% or the lower limit of normal (LLN) according to local institution ranges of normality.
You may not be if
More than 1 previous systemic anti-cancer therapy line
Patients with corneal epitheliopathy or any eye disorder that may predispose the patients to this condition at the discretion of the investigator in consultation with the ophthalmologist.
Brain metastases, meningeal tumours or other metastases in the central nervous system
Evidence of history of bleeding diathesis.
Ongoing or active infection (bacterial, fungal, or viral) of National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 4.03 Grade \> 2.
