Investigate a Interaction of Candesartan and Atorvastatin in Healthy Male Sugjects

Exclusion Criteria

• •History of cardiovascular, respiratory, hepatic, renal, neuropsychiatric, endocrine, hematologic disease
• •Hypersensitivity reactions to drugs or significant hypersensitivity reactions in the history of Candesartan and Atorvastatin
• •Hypotension (DBP ≤ 100 mmHg or SBP ≤ 95mmHg) and hypertension (SBP ≥ 150 mmHg or DBP ≥ 95 mmHg)
• •Gastrointestinal disease affected the absorption of medications
• •Genetic disease of Galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption
• •AST or ALT \> 2 x normal range
• •Total bilirubin \> 2.0 mg/dl
• •CK \> 2 x normal range
• •eGFR \< 60 mL/min/1.73m2
• •Subject who have drunken habitually (alcohol more than 21 units/week, 1 unit = 10 g = 12.5 mL of pure alcohol) or who are unable to quit drinking during this study
• •Subject who have smoke habitually more than 10 cigarettes/day or who are unable to quit smoking during this study
• •Subject who treated with any investigational drugs within 90 days before the administration of investigational drug
• •Previously donate whole blood within 60 days or component blood within 30 days or transfusion within 30 days
• •Subject who treated with any drug within 30 days can affect absorption, distribution, metabolism, excretion of candesartan or atorvastatin
• •Subject who treated with any Rx only drug or herbal drug within 14 days and any OTC within 7 days
• •History of drug abuse
• •Genetic neuromuscular disorder or family history of neuromuscular disorder
• •Unusual diet affected the absorption, distribution, metabolism, excretion of medications
• •Subjects deemed ineligible by investigator based on other reasons