Safety, Blood Levels and Effects of AUT00206

Exclusion Criteria

• •not healthy (clinically significant abnormality in screening tests, which include ECG, vital signs, physical examination, and laboratory safety tests of blood and urine);
• •severe hearing impairment, or MoCA score of less than 22 points (Part B only);
• •abuse of alcohol or drugs;
• •taken prescription medicine during the 28 days before dosing;
• •taken other medicine (except paracetamol), herbal remedies or dietary supplements during the 7 days before dosing; have had a serious reaction to any medicine, particularly medicines that work in the same way as the study medicine;
• •have had any condition or operation that might affect the way the body absorbs medicines;
• •have had any clinically significant disease;
• •have ever attempted suicide or thought or talked about suicide, using the C-SSRS (Part B only);
• •objection by GP on medical grounds;
• •have donated blood, or taken part in another study, within the past 3 months; or don't agree not to donate blood, or take part in another study, during the 3 months after this study
• •smoking of more than 5 cigarettes daily
• •unwilling to cooperate with the requirements of the protocol