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COMPLETEDNCT02587728

Carpal Tunnel/Amyloidosis Blood Sample Study

Carpal tunnel is an early manifestation of amyloidosis in a significant minority of patients. This specimen collection protocol will allow the investigators to screen patients with carpal tunnel syndr...

Lead sponsor: University of Miami•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Miami

The investigators propose to assess a high risk population of patients, those with carpal tunnel syndrome, and systematically assess them for Amyloid Light-chain (AL) amyloidosis and Transthyretin-Related Amyloidosis (ATTR) with simple laboratory blood tests. The combination of serum immunofixation electrophoresis together with serum free light chain (FLC) assay approaches 100% sensitivity for identifying the monoclonal protein underlying the illness in patients with AL amyloidosis. In addition to this, testing for transthyretin gene mutations will allow the investigators to identify patients with ATTR. The investigators believe this simple screening panel (serum immunofixation and serum FLC assay and transthyretin mutation analysis) may allow the investigators to identify patients early in the course of their disease, at which point the investigators can intervene with effective treatment and spare patients a significant amount of morbidity and mortality.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•1\. Patients with diagnosed carpal tunnel syndrome based on Electromyography (EMG) results.
•2\. Patients with electrographic confirmation of median neuropathy at the wrist
•3\. Age ≥18 years
•4\. Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria

•1\. Patients receiving hemodialysis
•2\. Known amyloidosis

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: August 26, 2021Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment10

Start dateFeb 2016

Last updatedAug 26, 2021

Condition

Carpal Tunnel Syndrome Amyloidosis

Locations shown

University of Miami

Miami, Florida

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 26, 2021Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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