Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease

Exclusion Criteria

• •Pregnant women or women with potential childbearing
• •Patients severe adverse events or hypersensitive to statin or patients with multi-drug allergy.
• •Who had received drug that have a drug interaction with statin (strong inhibitor of cytochrome p-450 3A4 or 2C9)
• •Patients with risk factors for myopathy with hereditary muscle disorder, hypothyroidism, alcohol use disorder, severe hepatic dysfunction (3 times normal reference values) or rhabdomyolysis
• •Life expectancy \< 3 years
• •Patient with who can not be followed up for more than 1 year
• •Patients who cannot understand or read the consent form