Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
DSM-IV Bipolar I Disorder;
having had a mood episode within the preceding year; DSM-IV rapid cyclers will be permitted to participate in this study;
males or females between 18 and 65 years of age;
ongoing illness symptoms including significant functional impairment;
documented history of treatment resistance, defined as persistent symptoms despite simultaneous, adequate treatment with at least two medications: one mood stabilizer (lithium or valproate) + antipsychotic OR two mood stabilizers (at least one of them being lithium or valproate).
each patient must have a level of understanding sufficient to agree to all the tests required by the protocol and must sign an informed consent document
You may not be if
patients with onset of illness after age 40 or illness resulting from secondary causes
women who are pregnant or breastfeeding, or not using adequate contraception
unstable medical illnesses
clinically significant abnormal laboratory tests
current active alcohol or substance abuse
severe personality disorders
contraindication to the use of clozapine or previous treatment with clozapine
