L-Threonic Acid Magnesium Salt (L-TAMS) in ADHD

Exclusion Criteria

• •A history of intolerance to magnesium supplementation, or the ingredients in MMFS202 (6-hour release) AND MMFS302 (12-hour release)
• •Pregnant or nursing females
• •A known unstable medical illness including hepatic, renal, gastroenterological, respiratory, cardiovascular (including hypertension ≥ 140/90 mmHg at screening), endocrinologic (e.g. thyroid), neurologic (e.g. seizure), immunologic, hematologic, or psychiatric (other than ADHD) disorder); individuals with kidney dysfunction will be excluded, as dysfunctional kidneys may have difficulty clearing the magnesium from the body (which can result in dangerously high magnesium levels); individuals with heart block will be excluded from the study
• •Any medical condition that the Principal Investigator (PI) believes will be exacerbated by study participation
• •A history of cancer (except localized skin cancer without metastases or in situ cervical cancer) within 5 years prior to screening
• •A known history of narrow-angle glaucoma
• •Current (within 3 months) DSM-V criteria for abuse or dependence with any psychoactive substance other than nicotine
• •Intelligence Quotient (IQ) less than 80 (based on the Wechsler Abbreviated Scale of Intelligence-II Full Scale IQ calculation)
• •Multiple adverse drug reactions
• •Any other concomitant medication with primarily central nervous system activity as specified in the study protocol
• •Current use of a monoamine-oxidase inhibitor (MAOI) or use within the past two weeks
• •Current use of antibiotics, as the study agent may reduce the absorption of antibiotics
• •Subjects may not take any of the following substances for at least 7 days prior to baseline and throughout the study: Calcium channel blockers; any psychoactive medications; any medications known to interact with magnesium; supplemental magnesium or any magnesium-containing products; all dietary or herbal supplements or products including those purported to improve memory, improve sleep, or decrease stress.
• •Investigator and his/her immediate family; defined as the investigator's spouse, parent, child, grandparent, or grandchild