a4b7 Integrin in Eosinophilic Esophagitis

Exclusion Criteria

• •1. Another disorder that causes esophageal eosinophilia (e.g., hypereosinophilic syndrome, Churg-Strauss, parasitic infection)
• •2. History of abnormal gastric or duodenal biopsy or documented GI disorders other than EoE (e.g., celiac disease, Crohn's disease or H. pylori infection)
• •3. History of the following GI surgeries: fundoplication, gastric surgery or surgery for esophageal atresia
• •4. Use of systemic immunosuppressive or immunomodulating agents (oral prednisone, anti-immunoglobulin E (IgE) monoclonal antibody (mAb), methotrexate, cyclosporine, INFα, or anti-TNF) within six months prior to study entry.
• •5. A stricture on endoscopy that prevents passage of the endoscope
• •6. Participation in any investigational drug or device study within 30 days prior to study entry.
• •7. Female subjects who are pregnant or nursing.
• •8. Chronic infections such as HIV, hepatitis B or C, active mycobacterial (TB) or fungal infections.
• •9. Neoplasm or a history of malignancy in the preceding 5 years.
• •10. Concurrent infection or disease that may preclude assessment of eosinophilic esophagitis.