A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection

1. Inclusion criteria * Patients diagnosed as acute upper respiratory infection. * Patients with acute upper respiratory infection diagnosed as Traditional Chinese Medicine(TCM) syndrome wind-heat attacking the Lung (type of heat pathogen invading the defensive Qi of the lung). * Acute upper respiratory infection onset time is less than 36 hours. * Patients aged 18 to 70 years old. * Patients agreed to participate this study and sign the informed consent. 2. Effectiveness evaluation * TCM symptoms: fever, sore throat, cough with or without expectoration, headache, thirst, change of tongue body, tongue coating and pulse. * Signs: swollen tonsils, pharyngeal hyperemia. * Body temperature 3. Safety evaluation * Clinical symptoms and signs of adverse event reaction * Signs: blood pressure, respiration, heart rate, body temperature; * Routine blood test and urine routine; * Liver function and renal function: Alanine transaminase (ALT)、glutamic-oxalacetic transaminease(AST)、serum creatinine(SCr)、urea nitrogen(BUN) ; * Incidence of electrocardiogram(ECG) abnormalities. 4. Cost-effectiveness evaluation cost calculation * The direct medical costs include: the registration expenses, examination expenses, laboratory test expenses, Treatment costs, Chinese medicine expenses, Chinese herbal medicine expenses, western medicine expenses; Indirect medical costs: transportation costs, lost income patients; Adverse drug reactions cost: the cost of treatment due to adverse drug reactions. * Effect Evaluation:Symptoms and signs score, physical examination, the incidence of complications. 5. Number of participants 600 participants will be divided into two groups, the experimental group (n=300)and the control group (n=300).Each group will be stratified into three layers according to fever, sore throat, fever and sore throats. 100 patients will be included in each level. 6. Dose regimen * treatment group: Jinyebaidu granule, blunt, 10g/time, three times a day; Compound Shuanghua granules placebo, blunt, 6g /time, 4 times a day. * Control group: Compound double flowers particles, blunt, 6g/time, 4 times a day; Jinyebaidu Granule placebo, blunt, 10g/time, three times a day. 7. Course of treatment：5 days