VEST III PMS Clinical Protocol

Exclusion Criteria

• •1. Concomitant non-CABG cardiac procedure
• •2. Prior cardiac surgery
• •3. Emergency CABG surgery (cardiogenic shock, inotropic pressure support, IABP)
• •4. Contraindication for on-pump CABG with cardioplegic arrest (e.g. severely calcified aorta)
• •5. Calcification at the intended anastomotic sites, as assessed upon opening of the chest, before randomization
• •6. Severe vein varicosity
• •7. Prior debilitating stroke less than 1 year before surgery
• •8. Severe renal dysfunction (Cr\>2.0 mg/dL or \>177 μmol/L)
• •9. Women of child bearing age
• •10. Concomitant life-threatening disease likely to limit life expectancy to less than 5 years
• •11. Indication for Warfarin up to time of surgery
• •12. Inability to tolerate or comply with required normal post-operative drug regimen (antiplatelet, statin and beta-blockers) that cannot adequately be controlled.
• •13. inability to take aspirin
• •14. Contraindication to intravascular contrast material that cannot be adequately controlled with pre-medication
• •15. Inability to comply with required follow-ups including angiographic and/or CT imaging methods.
• •16. Participating in any other investigational study for either drug or device which can influence collection of valid data under this study