Hospital Affiliated to Military Medical Science, Beijing
Age
18–69
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
18≤aged\<70
pathologic diagnosis of invasive breast cancer，staging ii to iii，the diameters≥2cm indicated by MRI or axillary lymph node（+）
Immunohistochemical（IHC） positive for 3+ or FISH（+）
clear hormone receptor（HR） status
Eastern cooperative oncology group(ECOG)=0/1
LVEF≥55%
pathologic grading of Miller and Payne
screening laboratory values with the following parameters：absolute neutrophils acount：≥1500/mm3,total bilirubin:≤2.0×ULM,Aspartate transaminase (AST)/ALT≤2.5×ULM,platelet≥80000/mm3，serum creatinine≤1.5×ULM
no pregnant or nursing
signed Informed consent forms
You may not be if
prior exposure to any treatments for breast cancer
