Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Pathologically confirmed metachronous or synchronous metastatic colorectal cancer
No prior chemotherapy with the exception of adjuvant chemotherapy completed ≥ 6 months prior to enrollment
Signed written informed consent obtained prior to any study specific screening procedures
Patients willing to provide a blood sample for Translational Research

No tumor block available
Previous malignancy in the last 5 years
Medical, sociological, psychological or legal conditions that would not permit the patient to sign informed consent

RAS Mutation Testing in the Circulating Blood of Patients With Metastatic Colorectal Cancer