Investigation of Kava Effects on NNK Metabolism

Exclusion Criteria

• •Known hepatobiliary disease or impairment
• •History of gastric bypass surgery, gastric banding, bowel resection, malabsorption syndromes such as celiac sprue or pancreatic insufficiency, or other conditions that may affect the absorption of kava
• •Chronic medication use that cannot be safely stopped
• •Use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes)
• •Major or chronic medical medical disease, including heart disease, poorly controlled diabetes, etc., to be adjudicated by the principal investigator
• •Women who are pregnant, intend to become pregnant within 3 months of the study period, or who are breastfeeding
• •Current or recent (within 12 months) problems with drug use or alcohol dependence by self-report
• •Antibiotic use within 2 months of study enrollment by self-report
• •Alcohol dependence, abuse, or history of dependence/abuse by self-report