Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Centre Henri Becquerel
The aim of the study is to compare the biodistribution of the two tracers specific for hypoxia in patients with non-small cell lung cancer.
Two PET scans will be performed with FAZA and F-Miso tracers. The time between these twi PET scans will be 24 hours.
another 24 hours after the late PET scan, the surgery will be done and a piece of tumor will be collected.
Piece of tumor will be analysed by immunohistochemistry for hypoxia markers.
The results of immunohistochemistry will be correlated with the biodistribution of the two tracers.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or female
More than 18 years old
Patient with non-small cell lung cancer (histologically proved)
PS inferior or equal to 1 (good general state)
Patient must have surgery for their non-small cell lung cancer
Stage of tumor Superior or equal to 2a without metastasis
Tumoral fixation with 18-FDG-PET superior to mediastinal background noise
Written inform consent
You may not be if
Histology other than primitive non-small cell lung cancer
In situ form at the histological study
Patient without evaluable target
No fixation on the pretherapeutic FDG-PET scan
PS Superior or equal to 2
neoplastic disease (less than 2 years or progressive)
