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Keep this study
Lead
Pediatrix
This is a multicenter randomized double blinded trial that hopes to prospectively evaluate the impact of one versus two courses of antenatal steroids on the incidence of major neonatal morbidity including respiratory distress syndrome in pregnant women with a singleton gestation between 24w0d - 32w6d gestation who have documented premature rupture of the membranes.
Age
18–65
Sex
FEMALE
Healthy volunteers
Accepted
You may be eligible if
Participants age 18 years or older
24w0d to 32w6d weeks gestation
Singleton pregnancy
Received first course of ACS at or prior to 31w6d gestation
Began first course of ACS at least 7 days ( =/\> 168 hours) prior to randomization
Expectant management planned
Premature Ruptured membranes (PROM) before onset of labor
You may not be if
Known major fetal anomalies
Multiple gestation
Not a candidate for expectant management
Clinical chorioamnionitis (two or more of the following: temperature \> 38.0 degrees centigrade; uterine tenderness; foul smelling vaginal discharge or amniotic fluid; maternal tachycardia \>100 bpm; fetal tachycardia \>160 bpm; maternal White Blood Cell (WBC) count \>20 X 109/L; C-Reactive Protein (CRP) \> 5.9
Already receiving corticosteroids for another condition
Any contraindications to the maternal use of corticosteroids
Clareo Health | Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes
