1. Patients of chronic liver disease with history of upper Gastro Intestinal bleed.

2. Patients of acute on chronic liver failure

3. Thrombosis of splenoportal axis

4. Hepatocellular carcinoma

5. Patients who were on primary variceal ligation sessions as prophylaxis

6. Patients who are beta blocker intolerant (Prior h/o hypotension, bradycardia).

7. Patients who are contraindicated for beta blockers {H/O COPD (Coronary Obstructive Pulmonary Disease), heart block, refractory Ascites, SBP(Spontaneous Bacterial Peritonitis) , HRS(Hepato Renal Syndrome)}.

8. Failure to give consent for inclusion in the study

To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices.

What this study is about