diagnosis of depressive episode (F32.X, F33.X) with duration less than \< 6 months
max. three previous episodes of illness
no manic or hypomanic episodes in the past
current treatment with one antidepressant
MRI-compatibility
unequivocal understanding of study information and autonomous consent
for women: negative pregnancy test
for risk-group:
* 14 or more points on hypomania checklist (HCL-32)
* additionally at least one of the following four risk factors:
1. positive family history (i.e. first or second order relatives with BPD, schizoaffective or schizophrenic psychosis, mania or suicide attempt)
2. initial manifestation before 30 years of age
3. initial manifestation after childbirth
4. suicide attempt in the past
You may not be if
additional diagnoses of psychiatric disorders (Organic, including symptomatic, mental disorders \[F0X.X\]; mental and behavioural disorders due to psychoactive substance use \[F1X.X\]; schizophrenia, schizotypal and delusional disorders \[F2X.X\]; mental retardation \[F7X.X\])
chronic or acute physical disease
individuals who are in a dependence- or work-relation with the sponsor
limited or annulled legal capacity
court or administrative order for hospitalisation
for women: pregnancy, nursing period or unsafe contraceptive methods
for the risk group:
* clinical relevant changes in clinical chemistry, hematology, EEG or EKG
* known contraindication for quetiapine (e.g. hypersensitivity to \[active\] ingredient\[s\], HIV-protease inhibitors, antimycotics, antibiotics)
Clareo Health | Effect of Quetiapine on Brain Activity Patterns in Patients With Heightened Risk of Bipolar Disorder
