Lead Sponsor

Advanced Circulatory Systems

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•≥18 years of age
•intubated and mechanically ventilated on a volume controlled mode
•head injury or other intracranial pathology and compromised cerebral perfusion
•arterial line in place or alternative with continuous pressure monitoring
•SpO2 ≥90%
•mean arterial pressure \>55
•admission to ICU or about to undergo neurosurgery with planned placement of an invasive intracranial pressure monitor
•inclusion presents no significant delays to planned emergent neurosurgery
•prior written informed consent

•cardiac or pulmonary injury
•confirmed pneumothorax or hemothorax
•serious neck injury resulting in neck swelling with jugular venous compression
•evidence of ongoing uncontrolled bleeding
•respiratory disease such as COPD, interstitial lung disease, or other parenchymal or pulmonary vascular disease
•marked hypertension at time of device use defined as systolic blood pressure \>180 mmHg
•congestive heart failure
•women with positive serum or urine pregnancy test or breast feeding