Subject has air leak only on forced exhalation or cough

Subject has sepsis

Subject has pneumonia

Subject has Acute Respiratory Distress Syndrome (ARDS)

Subject is not an appropriate candidate for, or unable to tolerate, flexible bronchoscopy procedures

Subject has undergone a bone marrow transplant

Subject has a primary pneumothorax

Subject has undergone a prior intervention (including pleurodesis, surgery, blood patch, and pneumoperitoneum) or valve placement.

Spiration Valves Against Standard Therapy