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COMPLETEDNCT02376738

Regional Activation of Leukocytes in Coronary Artery Disease

This study aims to evaluate the role of leukocyte activation in coronary artery disease

Lead sponsor: Sint Franciscus Gasthuis•2 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Sint Franciscus Gasthuis

1. The primary aim of REAL CAD is to determine regional differences of leukocyte activation in different vascular beds in vivo. 2. The secondary aim is to investigate differences in leukocyte activation between diabetic and CAD subjects and patients suffering from both. 3. The third aim is to investigate the relationship between complement components, triglycerides and leukocyte activation markers in order to gain more insight into the causative processes leading to activation of leukocytes. 4. The fourth aim is to get more insight in the MBL genotypes and serum levels of CAD and/or diabetic patients and the 'healthy' groups included in our study.

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Subjects scheduled to undergo a coronary catheterization
•Provide written informed consent
•Aged \>18 and \<75 years
•BMI \< 35 kg/m2

Exclusion Criteria

•Emotionally and intellectually not capable to decide about participation in the study and the consequences of participation. Subjects who are not able to understand the patient information
•CRP \> 20 mg/l
•Unstable angina pectoris
•CABG or PTCA during the last 6 months
•Alcohol use \> 2 units/day
•Aberrations in kidney, liver and thyroid function
•Use of any experimental medication within 6 months of the catheterization
•The use of immunosuppressive drugs

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: March 3, 2015Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment97

Start dateJul 2007

Last updatedMar 3, 2015

Condition

Inflammation Coronary Artery Disease

Locations shown

Sint Franciscus Gasthuis

Rotterdam, South Holland

Sint Franciscus Gasthuis

Rotterdam, South Holland

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 3, 2015Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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