Multifocal/multicentric diseases noticed before surgery.

Inflammatory breast cancer or invasive micro-papillary carcinoma of the breast confirmed by pathology before surgery.

Tumor size \> 5 cm revealed by physical examination, Ultrasound or mammography before surgery.

Tumor size/breast size ratio \>0.5 revealed by by physical examination, Ultrasound or mammography before surgery.

Have other malignant tumors.

Have severe co-morbidities that compromise the patients' compliance to our protocol, or endanger the patients.

Participated in other clinical trials.

Pathologically confirmed metastatic breast cancer, bilateral breast cancer or DCIS patients.

Patients with any organ failure.

Pregnancy women

Patients who desire to have mastectomy before surgery.

Oncoplastic Breast-conserving Surgery in Non-metastatic Breast Cancer Patients