Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium

Exclusion Criteria

• •1. Atrial fibrillation due to a reversible cause, moderate or severe mitral stenosis, or conditions other than atrial fibrillation that require anticoagulation (e.g., a prosthetic heart valve)
• •2. Prior apixaban, dabigatran, rivaroxaban use.
• •3. A need for aspirin at a dose of \>165 mg a day or for both aspirin and clopidogrel,
• •4. Renal insufficiency (serum creatinine level of 12.5 mg per deciliter or calculated creatinine clearance of \<50 ml per minute).
• •5. Serious bleeding event in the previous 6 months or a high risk of bleeding (eg, active peptic ulcer disease, a platelet count of \<100,000/mm3 or hemoglobin level of \<10 g/dL, stroke within the previous 10 days, documented hemorrhagic tendencies, or blood dyscrasias)
• •6. Weight in excess of 325 pounds
• •7. Resting hypotension (systolic blood pressure of \<90mmHg) or resting hypertension (systolic blood pressure of \>170mmHg or diastolic blood pressure of \>110 mmHg).
• •8. History of active malignancy requiring concurrent chemotherapy.
• •9. Any unstable medical, psychiatric, or substance abuse disorder that in the opinion of the principal investigator is likely to affect the subject's ability to complete the study.
• •10. Known allergy to iodinated contrast material
• •11. Pregnancy or breast feeding