Benefits of Exercise Training in Women With Ischemic Syndrome

Exclusion Criteria

• •1. Acute coronary syndrome (defined by WHO), cardiogenic shock or requiring inotropic or intra-aortic balloon support;
• •2. Planned percutaneous coronary intervention or coronary artery bypass graft or established obstructive CAD with ischemia eligible for revascularization,
• •3. Acute myocardial infarction;
• •4. Patients with concurrent cardiogenic shock or requiring inotropic or intra-aortic balloon support;
• •5. Prior non-cardiac illness with an estimated life expectancy \<4 years;
• •6. Unable to give informed consent;
• •7. Allergy or contra-indication to cardiac magnetic resonance imaging, including renal failure, claustrophobia, and asthma, uncontrolled moderate hypertension (sitting blood pressure \>160/95 mmHg with measurements recorded on at least 2 occasions), conditions likely to influence outcomes: Severe lung, creatinine \>1.8 or CrCl ≤ 50ml/min) or hepatic disease;
• •8. Contraindications to adenosine or regadensoson (Lexiscan)
• •9. Surgically uncorrected significant congenital or valvular heart disease and other disease likely to be fatal or require frequent hospitalization within the next six months;
• •10. Adherence or retention issues;
• •11. Unwilling to complete follow-up evaluation;
• •12. Aortic stenosis (valve area \<1.5cm);
• •13. Left ventricular systolic dysfunction (ejection fraction \<35%);
• •14. Taking potent CYP3A4 inhibitors (ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir);
• •15. Women who are pregnant.
• •16. Allergy to animal dander.
• •17. Unable to perform exercise