1. Diabetes mellitus.

2. Chronic kidney disease (estimated glomerular filtration rate \<60 ml / minute / 1.73 m2 of body surface area.

3. Smoking.

4. Lung disease, liver disease or active cancer

5. Any factor that, in the opinion of the investigator, decreases short-term survival

6. Psychiatric illness

7. Inability to provide informed consent

8. Established heart disease (previous myocardial infarction, heart failure, valvular heart disease, cardiomyopathy, atrial fibrillation or any significant cardiac arrhythmia)

9. History of cerebrovascular disease

10. History of orthostatic hypotension.

11. History of syncope.

12. History of allergy of adverse effects to study medications or drugs of the same pharmacologic classes.

INTERVENCION Trial

What this study is about