Phase II of High-dose Therapy in Elderly Patients With Relapsed Aggressive NHL or Resistant to First Line Therapy

Inclusion Criteria

• •Diagnosis of NHL
• •relapse and refractory pts
• •age ≥ 65 and ≤75
• •ECOG performance status \<2
• •FIT patients (Instrumental Activity of Daily Living (IADL)=8, Activity of Daily Living (ADL)=6, Cumulative Illness Rating Scale (CIRS) =0 SCORE=3-4, \<5 SCORE=2 )
• •evaluable disease
• •no RT since 3 week
• •absolute neutrophil count \>= 1500/mm3 and platelets \>= 100.000/106L
• •Creatinin \<= 1.5 mg/dL and clearance \>40 ml/min/24 h
• •bilirubins \< =2 mg/dL
• •forced expiratory volume \>50% - arterial pressure O2 \>70 mmHg
• •no other neoplastic disease
• •Life expectancy\> 3 months
• •signed informed consent