Bortezomib, Lenalidomide, and Dexamethasone in Treating Patients With Multiple Myeloma Undergoing Stem Cell Transplant

Exclusion Criteria

• •Patients with a history of recent (\< 6 months) myocardial infarction, unstable angina, difficult to control congestive heart failure, uncontrolled hypertension, difficult to control significant cardiac arrhythmias, or arrhythmia associated with prolonged QT interval
• •Pregnant or nursing women; women of child-bearing potential must have a negative pregnancy documented within one week of registration; women/men of reproductive potential may not participate unless they have agreed to use two forms of effective contraceptive method
• •Patients with a grade 3-4 neuropathy related to prior exposure to bortezomib, thalidomide, or other agents
• •Human immunodeficiency virus (HIV) positive patients
• •Transaminases \> 2 x normal values
• •Bilirubin \> 2 x normal values
• •Active uncontrolled infection
• •History of significant psychiatric illness; steroid induced psychosis