Observational Study to Evaluate Long-term Safety and Biodegradability of YVOIRE Classic s

Exclusion Criteria

• •1. Subjects who are sensitive to hyaluronic acid or any excipients of YVOIRE classic s
• •2. Subjects who have received permanent implantation (silicone, PAAG, PMMA, CaHA etc) on the nasolabial folds
• •3. Subjects who have received nonpermanent aesthetic treatments, such as botulinum toxin injection or filler on the nasolabial folds within 9 months before screening
• •4. Subjects who have received face lifting or plastic surgery on face within 9 months before screening
• •5. Subjects who have received laser therapy on the nasolabial folds, chemical peeling or peeling on face within 3 months before the screening
• •6. Subjects who have any skin diseases (including inflammation and skin cancer) or infectious diseases on the injection sites
• •7. Subjects who tend to have hypertrophic scars
• •8. Subjects with a history of streptococcal disease, severe allergy or anaphylaxis or bleeding disorders.
• •9. Women in pregnancy or lactation