Cytoreduction With or Without Intraoperative Intraperitoneal Hyperthermic Chemotherapy (HIPEC) in Patients With Peritoneal Carcinomatosis From Ovarian Cancer, Fallopian Tube or Primary Peritoneal Carcinoma

Inclusion Criteria

• •Peritoneal carcinomatosis arising from ovarian epithelial carcinoma (stage III or higher), carcinoma of the fallopian tube and primary peritoneal carcinoma.
• •Residual tumor \< 2.5 mm after completion of cytoreductive surgery.
• •Aged \< 75 years.
• •Baseline ECOG 0-1 (Eastern Cooperative Oncologic Group).
• •Adequate bone marrow function with hemoglobin ? 8 g/dl (after correction for iron deficiency anemia), white blood cell count ? 3,000/mm3, platelets ? 100,000/mm3.
• •Adequate renal function with creatinine ? 1.5 mg/ dl.
• •Adequate liver function with bilirubin levels ? 1.5 mg / dl and AST and ALT ? 80 IU / L.
• •Optimal cardiopulmonary function.
• •In recurrences, disease-free interval \> 6 months.
• •Voluntary and signed written informed consent.