Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Pfizer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Evidence of histological or cytologically confirmed diagnosis of locally advanced or metastatic EGFRm (del19 or L858R) NSCLC that is resistant to standard therapy. Patients must have progressed on treatment with an EGFR TKI, and may have also received other line of therapy.
Tissue available (formalin fixed paraffin embedded (FFPE) block or 10 unstained sections (5 micron)
Patients must be willing to participate in additional PK studies as required (cohort dependent); patients will be informed of which PK studies are required prior to consenting for study participation
Adequate Bone Marrow Function (Complete Blood Count laboratory test results)
Adequate Liver Function (Laboratory test)
You may not be if
Previously diagnosed brain metastases, unless the patient has completed their treatment and has recovered from the acute effects of radiation therapy or surgery prior to the study registration, have discontinued corticosteroid treatment for these metastases for at least 2 weeks and are neurologically stable
Systemic anti-cancer therapy within 4 weeks of starting study treatment excluding EGFR TKIs. Patients on EGFR TKIs must discontinue the agent for a minimum of 5 days prior to starting study drug
Hypertension that cannot be controlled by medication (150/100 mmHg despite optimal medical therapy).
Clareo Health | A Study For Patients With EGFRm (Epidermal Growth Factor Receptor Mutant) Lung Cancer
