Age

18–90

Sex

ALL

Healthy volunteers

Not accepted

Age ≥18
WHO Performance status 02 (Appendix A)
Histologically proven non small cell lung carcinoma, distal oesophageal carcinoma or pancreatic adenocarcinoma
Clinical decision made to proceed with a course of radiotherapy of curative intent with or without concurrent chemotherapy
Measurable primary tumour and/or locoregional metastatic lymph nodes on preradiotherapy imaging
Able to provide fully informed written consent
Able to lie flat for 1 hour
Not be pregnant or breast feeding. Female patients of childbearing potential must agree to use effective contraception, be surgically sterile, or be postmenopausal.

1. Hypersensitivity to Fluorine18 fludeoxyglucose (FDG)
2. Hypersensitivity to iodinated contrast media
3. Poorly controlled diabetes
4. Acute renal failure or moderate renal impairment (estimated glomerular filtration rate \< 30 mL/min)
5. Claustrophobia precluding imaging
6. Uncontrolled pain
7. Urinary incontinence
8. Female patients must not be pregnant and if of child bearing age using adequate contraception
9. Breast feeding
10. Serious psychiatric comorbidity

Evaluation of 4D-contrast Enhanced PET-CT in Tumour Volume Definition