Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study

Exclusion Criteria

• •active tobacco smoking or use of smokeless tobacco products containing nicotine,
• •active cardiac or central nervous system disease,
• •history of adverse reaction to nicotine or nicotine-containing products,
• •patients with extensive irreversible pulmonary fibrosis (based upon lung biopsy or high resolution CT scan criterion) or inability to provide consent.
• •The subject will be excluded if they have a smoking history of greater than 20 pack years, or a diagnosis of other significant respiratory disorder other, than sarcoidosis that, in the opinion of the investigator, would complicate the evaluation of response to treatment; or, history of substance abuse (drugs or alcohol) within 3 years prior to screening or other circumstances (e.g., psychiatric disease) that could interfere with the subject's adherence to protocol requirements or increase their risk of drug (nicotine) dependence.