The Impact of Arousal Threshold in Obstructive Sleep Apnea

Exclusion Criteria

• •Any known unstable cardiac (apart from treated hypertension), pulmonary (including asthma), renal, neurologic (including epilepsy), neuromuscular, or hepatic disease.
• •Susceptible to stomach ulcers.
• •Pregnant women or Nursing mothers
• •Using positive airway pressure (PAP) therapy over one week or longer
• •Body weight \<55kg
• •History of hypersensitivity to Afrin, Lidocaine and/or Donepezil
• •History of bleeding diathesis and/or gastrointestinal bleeding.
• •Use of any medications that may affect sleep or breathing.
• •A psychiatric disorder, other than mild depression; e.g. schizophrenia, bipolar disorder, major depression, panic or anxiety disorders.
• •Substantial cigarette (\>5/day), alcohol (\>3oz/day) or use of illicit drugs.
• •More than 10 cups of beverages with caffeine (coffee, tea, soda/pop) per day.
• •Deprived from sleep in the recent one week
• •Desaturations to below 70% lasting greater than 10 seconds in duration per event in the sleep study (without Oxygen).