Dose-dense ABVD First Line Therapy in Early Stage Unfavorable Hodgkin's Lymphoma

Exclusion Criteria

• •Concomitant cardiac, pulmonary, neurologic, psychiatric or metabolic severe disease.
• •Uncontrolled diabetes mellitus (with fasting glucose levels above 200mg/dl)
• •Other prior malignancies except for adequately treated basal cell carcinoma, squamous cell carcinoma of the skin, carcinoma in situ of the cervix, carcinoma in situ of the breast or other cancer from which the patient has been disease-free for ≥ 3 years
• •Patients with a known history of HIV seropositivity
• •Active HCV infection (PCR + ; AST\> 1.5-2x UN)
• •Woman who is pregnant or breast feeding. Fertile patients not willing to use effective contraception during the study and 3 months after the end of treatment. Women of childbearing potential (WOCBP) are defined as sexually mature women who have not undergone a hysterectomy or who have not been naturally postmenopausal for at least 12 consecutive months.
• •Negative pregnancy test at baseline is required (serum β HCG).
• •Male patient whose sexual partner(s) are WOCBP who are not willing to use a effective contraception during the study and 3 months after the end of treatment
• •Nodular lymphocyte prevalence histological subtype