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Eliminate Coronary Artery Disease | Clinical Trials | Clareo Health

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TERMINATEDPhase 2NCT02245087

Eliminate Coronary Artery Disease

The purpose of this study is to determine whether pharmacologic lowering of low density lipoprotein cholesterol (LDL), initiated in healthy young to middle aged adults can eliminate or markedly reduce...

Lead sponsor: University Health Network, Toronto•3 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University Health Network, Toronto

Age

35 - 59 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Men 35-50 years of age
•Women 45 - 59 years of age (must be sterile or \>2 years postmenopausal)
•LDL cholesterol greater than 1.8 mmol/L (70 mg/dL) based on testing performed within 1 year
•One risk factor for Coronary Heart Disease other than lipid abnormality:
•Obesity and hypertension \[BP \>140 mmHg systolic and waist circumference \> 100 cm in men and \>90 cm in women\]
•family history of premature myocardial infarction \[\<60 years\]
•South Asian ethnic history
•currently smoking

Exclusion Criteria

•Currently taking cholesterol lowering medication
•Qualify for cholesterol lowering medication based on current guidelines
•Significant renal dysfunction (creatinine clearance \<30 ml/min)
•Significant hepatic dysfunction (AST/ALT \>2.0 times upper limit of normal)
•Active malignancy
•Diabetes
•Progressive or terminal illness, or other condition in which subject is unlikely to survive the study period
•Known allergy, hypersensitivity (anaphylaxis) ar adverse reaction to any statin
•Participation in a clinical trial (except observational studies) within previous 30 days
•Received any investigation product within 30 days prior to participation in this clinical trial
•Previously enrolled in this clinical trial

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: June 1, 2022Terms

Trial snapshot

StatusTERMINATED

PhasePHASE2

Enrollment28

Start dateAug 2014

Last updatedJun 1, 2022

Condition

Coronary Artery Disease

Locations shown

Dr. Killian De Blacam Family Medical Practice

Greater Sudbury, Ontario

Dr. Gregory Garrioch Family Medical Practice

Greater Sudbury, Ontario

Dr. Reena Dhatt

Greater Sudbury, Ontario

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 1, 2022Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions