Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Maastricht University Medical Center
With
Unilever R&D
Age
40–70
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Quetelet-index between 25-35 kg/m2
High-normal blood pressure defined as systolic blood pressure between 130-139 mmHg and/or diastolic blood pressure between 85-89 mmHg. Or stage I hypertension defined as systolic blood pressure between 140-159 mmHg and/or diastolic blood pressure between 90-99 mmHg.
Mean serum total cholesterol/HDL cholesterol ratio \< 8
Mean serum triacylglycerol \< 4.5 mmol/L
Mean plasma glucose \< 7.0 mmol/L
You may not be if
Unstable body weight (weight gain or loss \>2 kg in the past 3 months)
Use of antihypertensive or anticoagulant medication
Indication for treatment with medication according to the Standard for cardiovascular risk management of the Dutch general practitioners community (NHG)
Usage of non-steroidal anti-inflammatory drugs (such as aspirin, ibuprofen, naproxen) and not able or willing to stop taking them from at least 4 weeks prior to the study
Use of medication or a diet known to affect serum lipid or glucose metabolism
Women with expected changes in the use of oral contraceptives or estrogen replacement therapy during the study period
Women lactating, pregnant or intend to become pregnant during study
Active cardiovascular disease like congestive heart failure or recent (\<6 months) event (acute myocardial infarction, cerebro vascular accident)
Severe medical conditions that might interfere with the study such as diabetes mellitus, epilepsy, asthma, chronic obstructive pulmonary disease, inflammatory bowel diseases and rheumatoid arthritis
Smoking or recently quit smoking (\<1 years)
Abuse of drugs
More than 21 alcohol consumptions per week for men and 14 consumptions for women
Reported intense sporting activities \> 10 h/w
Not possible or difficult to venipuncture as evidenced during the screening visits
Use of an investigational product within the previous 30 days
Not willing to stop the consumption of vitamin supplements, fish oil capsules or products rich in plant stanol or sterol esters 3 weeks before the start of the study
Not willing to give up being a blood donor (or having donated blood) from 8 weeks before the start of the study and during the study
