Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Arkansas
With
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
30–70
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
age 30-70 yrs;
have patent and non-infected arteriovenous fistula or graft;
are receiving maintenance HD 3 times per week lasting for 3-4 hours;
serum albumin of ≥ 3.2 g/dl, serum phosphate of \<6.5 mg/dl, and serum hemoglobin of ≥9 mg/dl in consecutive two blood tests as per the National Kidney Foundation Disease Outcomes Quality Initiative (NKF KDOQI) guidelines \[subjects failing screening due to blood test will be allowed to be re-screened in 30 days\];
receiving stable or maintenance dose of iron or erythropoietin-stimulating agents, statins, angiotension receptor blockers and/or angiotension converting enzyme inhibitors, phosphate binders, vitamin D receptor analogs as these agents may influence cytokines proposed in the study;
meet the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for MDD;
have a Ham-D score \> 17
You may not be if
meet DSM-IV criteria for Bipolar Disorder or other psychotic disorder in the month prior to screening;
are taking antidepressants, anti-anxiety medications, or hypnotics (including Zyban for smoking cessation);
having failed to respond to or tolerate bupropion or fluoxetine in the past
allergic to fluoxetine or bupropion
known history of HIV/AIDS; No testing will be conducted for screening purposes
known history of alcohol or drug abuse or dependence within the month prior to screening based on clinical records;
history of myocardial infarction or heart failure within one month of screening or a history of seizures or stroke at any point;
history of chronic liver disease and diagnosis of hepatic encephalopathy based on clinical records;
currently diagnosed with cancer or receiving any cancer treatment;
history of any infection within the last 2 weeks ;
currently taking any antibiotics, anti-inflammatory, and immune-modulator agents;
recorded noncompliance with dialysis schedules; and
currently participating in clinical or behavioral intervention studies.
recorded noncompliance with dialysis schedules; and
currently participating in clinical or behavioral intervention studies
