Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ottawa Heart Institute Research Corporation
The hemodynamic definition of PH-LHD involves a mean pulmonary artery pressure (mPAP) \>25mm Hg at rest and pulmonary capillary wedge pressure (PCWP) of ≥15.The coexistence of mitral insufficiency is also a characteristic of PH-LHD. HFpEF is a condition caused by impaired relaxation of a stiffened myocardium as a consequence of an increased load to the left ventricle due to elevated systemic pressures.
Pulmonary hemodynamics can be used to classify PH LHD as either passive or reactive, irrespective of LV function. It has been suggested that diastolic pressure gradient (DPG) may offer added prognostic value as a more accurate indicator of pulmonary vascular remodeling.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients must be able to provide their written informed consent to participate in the study after having received adequate previous information and prior to any study specific procedures.
At least 18 years of age at the time of screening.
Patients with PH secondary to left heart disease (known as group II PH) defined as a mean PAP\>25 mmHg and a PCWP of ≥15 mmHg.
You may not be if
All other types of pulmonary hypertension including Dana Point Classification Group 1, 3, 5.
Type II Diabetes mellitus requiring medical therapy
Previous myocardial infarction within the 3 months prior to screening.
