Exercise Intervention in Preventing Breast Cancer Recurrence in Postmenopausal Breast Cancer Survivors

Inclusion Criteria

• •The study will be conducted in women who have been diagnosed with a first primary invasive estrogen receptor (ER) positive (+) breast cancer (stages I-IIIa) who are within the first 3 years post-treatment
• •The study will be conducted in postmenopausal women
• •Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation; should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
• •Postmenopausal, defined as meeting any of the following criteria:
• •* Periods stopped more than 6 months ago
• •* Bilateral oophorectomy
• •* Not already classified as pre- or peri-menopausal
• •* Started using hormone therapy for menopausal symptoms before periods stopped, and/or
• •* Hysterectomy before age 56 years but aged 56 years or more at baseline
• •Any body mass index (BMI)
• •Sedentary (have not participated in a regular exercise program in the past 12 months)
• •Nonsmokers (not smoking during previous 12 months)
• •Willing and able to travel to the exercise facility
• •Diagnosed with a first primary invasive ER+ breast cancer (stages I-IIIa)
• •Have undergone a lumpectomy or mastectomy
• •Have completed adjuvant chemotherapy and/or radiation within the past 3 years prior to study enrollment (when cytokine levels are predicted to be high) and able to initiate an exercise program
• •May use adjuvant endocrine therapy if use will be continued for duration of study period
• •All subjects must have the ability to understand and the willingness to sign a written informed consent