ZonMw: The Netherlands Organisation for Health Research and Development
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Essential hypertension
Stable blood pressure on treatment with Angiotensin Converting Enzyme Inhibitor (ACEI) or Angiotensin II Receptor Blocker (ARB) and hydrochlorothiazide
Age between 18 and 85 years
WHO performance status 0-1
Available for a time period of 15 weeks
Written informed consent
Dippers: Nocturnal blood pressure fall of 10-20% of daytime values.20
Non-dippers: -Nocturnal blood pressure fall of \<10% of daytime values
You may not be if
secondary cause of hypertension
use of ARB because of intolerability (e.g. dry cough) of ACEI
nocturnal blood pressure fall of \>20% or rise
renal insufficiency (GFR\<60 ml/min)
shift work
pregnancy or wish to get pregnant
use of other antihypertensive medication than ACEI, ARB, hydrochlorothiazide or a calcium channel blocker
use of sleeping medication
Clareo Health | Treatment of HYpertension: Morning Versus Evening
