The Effects of Cyclosporin A in a Low Humidity Environment, on the Ocular Surface

Exclusion Criteria

• •Compromised cognitive ability which may be expected to interfere with study compliance
• •Uncontrolled or poorly controlled diabetes or heart or pulmonary disease that could, in the judgment of the investigator, jeopardize subject safety or interfere with the interpretation of the results of the study
• •Known hypersensitivity to any components of the artificial tears or cyclosporin A eye drops Anticipated contact lens wear during the study
• •History of corneal transplant
• •Active ocular infection, uveitis or non-KCS related inflammation
• •History of cataract surgery within 3 months prior to enrollment
• •History of pterygium removal within 6 months prior to enrollment
• •Reduced corneal sensitivity
• •Initiation, discontinuation or change in dosage of hormone replacement therapy (HRT), fish oil, evening primrose, flaxseed, or black current seed oil supplements, antihistamines, cholinergic agents, beta-blocking agents, tricyclic or SSRI antidepressants, phenothiazines, or topical or systemic acne rosacea medications in two months prior to enrollment, or anticipated change in dosage during course of study
• •Topical ophthalmic medications within prior 4 weeks, or anticipated use of same during the study (except artificial tears)
• •Occlusion of the lacrimal puncta either surgically or with temporary collagen punctal plugs within three months prior to study, or anticipated use of same during study