α-TEA in Advanced Cancer

Exclusion Criteria

• •Active serious infection that could affect treatment.
• •Coagulopathy or need for anti-coagulation therapy.
• •Malabsorbtion state such as ulcerative colitis, previous surgical resection of \> 20% of intestine or stomach.
• •History of or active atrial fibrilliationfibrillation or supraventricular tachycardia
• •Cardiac ejection fraction less than the lower limit of normal on echocardiography
• •Right atrial enlargement on echocardiography
• •Active cardiac ischemia. Patients with a history of ischemia ameliorated with stent placement or coronary artery bypass grafting and who have no evidence of ischemia by exercise or physiological stress testing are eligible.
• •History of or active congestive heart failure
• •Patients with tumor that has invaded vagal nerve, carotid bodies, mediastinal structures, pericardium or myocardium.
• •Abnormal thyroid function, or euthyroid, but are on medication for thyroid disorders
• •Surgery or severe trauma within 4 weeks of study entry (minimally invasive procedures acceptable).
• •Active brain metastatic disease. Patients with brain metastases who have been treated with surgery, gamma-knife radiosurgery or radiation and no radiographic progression for at least 4 weeks and off steroids are eligible.
• •Any medical or psychiatric condition that in the opinion of the PI would preclude compliance with study procedures.
• •Vitamin E supplements
• •QTc greater than 450 msec at baseline (calculated using Bazett's formula), sick-sinus syndrome or other active cardiac disease.