Equivalence of New Breath AnalyzerCompared to Currently BreathID System in Assessment of Liver Function

Exclusion Criteria

• •1. Gastric bypass surgery or extensive small bowel resection
• •2. Total parenteral nutrition
• •3. Pregnant or breast feeding
• •4. Allergy to acetaminophen and/or other related medications.
• •5. Documented drug-related concurrent hepatotoxicity or drug-related silent steatosis or drug-related fibrosis (e.g. amiodarone, methotrexate and tamoxifen).
• •6. Uncontrolled malabsorption or diarrhea
• •7. Placement of a transjugular intrahepatic portosystemic shunt (TIPS)
• •8. Subject should not have taken any of the following for at least 48 hours prior to the breath test: Acyclovir, allopurinol, carbamazepine, cimetidine, ciprofloxacin, daidzein, (herbal) disulfiram, echinacea, enoxacin, famotidine, fluvoxamine, methoxsalen, mexiletine, montelukast, norfloxacin, phenylpropanolamine, phenytoin, propafenone, rifampin, terbinafine, ticlopidine, thiabendazole, verapamil, zileuton or oral contraceptives or any medication that might interfere with Methacetin metabolism or might affect CYP 1A2
• •9. Subject should not have taken amiodarone within the last 30 days prior to the breath test