Bioequivalence Study (Candesartan 8 mg and Amlodipine 5 mg)

Exclusion Criteria

• •1. Previous history or present of clinically significant hepatobiliary, nephrological, neurologic, respiratory, hemato-oncological, endocrine, urogenital, psychiatric, musculoskeletal, immune, otorhinolaryngological, cardiovascular system.
• •2. History of gastrointestinal disease or gastrointestinal surgery to affect drug absorption.
• •3. History of clinically significant allergies of amlodipine or candesartan or CCB or ARB or aspirin or antibiotic.
• •4. Subjects with galactose intolerance.
• •5. SBP ≥ 140 mmHg or\< 90 mmHg, DBP ≥ 95 mmHg or \< 60 mmHg, pulse ≥ 100 BPM.
• •6. AST or ALT \> 2\*ULN, total bilirubin \> 2\*ULN
• •7. Serum Creatinine \> ULN
• •8. Previous history or present of drug abuse.
• •9. Subjects treated metabolizing enzyme inducers or inhibitors such as barbitals within 1 month prior to the first dosing.
• •10. Subjects treated ethical drug or herbal medicine within 2 weeks, OTC or vitamin within 1 week prior to the first dosing.
• •11. Subjects treated IP within 2 months prior to the first dosing.
• •12. Subjects with whole blood donation within 2 months or component blood donation within 1 month or blood transfusion within 1 month prior to the first dosing.
• •13. Alcohol \> 21 units/week or cannot stop drinking.
• •14. Cigarette \> 10 cigarettes/day.
• •15. Subjects with the plan dental treatment(extraction, orthodontic, nerve treatment) or any surgery(plastic surgery, eye surgery - LASIK, LASEK).