Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Ghent
Age
1–18
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Parental consent must be granted
Patient age: 1y - 18 y
Documented diagnosis of hypertension as defined in the National Heart, Lung and Blood Institute (NHBLI) 4th report, 2004
No reversible cause found on diagnostic work-up for hypertension
Children older than 6y: 24h blood pressure monitoring confirms the diagnosis of hypertension
You may not be if
Pregnancy
Sexually active girls can only be included in the trial if they use an adequate form of birth control; during and until 30 days after ending the trial
Following abnormal laboratory values: Hyperkaliemia (serum potassium \> 5.3mmol/L); Anemia (hemoglobin \< 8g/dL); AST or ALT \> 3 times the upper limit of reference range; Total bilirubin \> 3 times the upper limit of reference range
Abnormalities of the oral cavity that can influence intake of medication
Known sensitivity to ACE-inhibitors
Known lactose intolerance
History of angioedema
Unilateral or bilateral stenosis of the renal artery
Diagnosis of heart failure (NYHA Class II-IV)
History of coarctation of the aorta
Current treatment with: other drugs influencing the renin-angiotensin-aldosterone system; lithium; potassium sparing diuretics; non-steroidal anti-inflammatory drugs; aspirin; oral antidiabetic medication
Clareo Health | Dose Titration of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension
