Lead Sponsor

University of Southern California

Collaborators

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Acute HF with signs or symptoms of volume overload \[i.e. elevated jugular venous pulsation (JVP), rales, edema\]
•Serum sodium \< 135 mEq/L at time of or within first 48 hours of hospitalization
•Randomized within 48 hours of presentation to hospital
•≥ 18 years of age
•Informed consent

•Severe symptomatic hyponatremia requiring acute treatment
•Severe renal impairment upon admission (creatinine clearance \< 20 mL/min)
•Renal replacement therapy dependent, or requiring upon admission
•Acute coronary syndrome on admission
•Requires or has a mechanical circulatory support device
•Evidence of cardiogenic shock requiring intravenous vasopressors
•Pregnancy
•Patient requiring concomitant use of strong CYP3A4 inhibitors (clarithromycin, ketoconazole, itraconazole, ritonavir, indinavir, nelfinavir, saquinavir, nefazodone, and telithromycin)