Anakinra in Infants and Children With Coronary Artery Abnormalities in Acute Kawasaki Disease

Inclusion Criteria

• •1. Infant or child aged 1 month to 17 years, who meets clinical criteria for KD according to American Heart Association guidelines (Table 2): Fever (T≥38oC or 100.4oC) ≥ 3 days and ≥ 2 clinical criteria with left anterior descending (LAD)/right coronary artery (RCA) Z score ≥ 3.0 or an aneurysm (≥ 1.5 x the adjacent segment) of one of the coronary artery segments
• •2. Patient presents within the first 20 days after fever onset
• •3. Parent or legal guardian able and willing to provide informed consent; adolescent or child assent as appropriate
• •4. Post-menarchal females: Negative pregnancy test at screening and willing to use two forms of contraception during the study
• •5. Males engaging in sexual activity that could lead to pregnancy willing to use a condom.