Phase II Investigation of Prostate Artery Embolization (PAE) Before Radical Prostatectomy in Prostate Cancer Patients

Exclusion Criteria

• •Active urinary tract infection
• •History of life threatening allergy to iodinated contrast agents
• •Any known condition that limits catheter-based intervention or is a contraindication to embolization (eg shunt or adverse arterial anatomy)
• •Patient is unable to undergo MRI imaging
• •Cardiac condition including congestive heart failure or uncontrolled arrhythmia, uncontrolled diabetes mellitus, significant respiratory disease, or known immunosuppression which required hospitalization within the previous 6 months
• •Baseline serum creatinine level \> 1.8 mg/dL
• •Baseline hemoglobin \< 8.0 g/dL
• •Active cystolithiasis or prostatitis
• •History of pelvic irradiation or radical pelvic surgery
• •Known major iliac arterial occlusive disease
• •Confirmed or suspected bladder cancer
• •Urethral strictures, bladder neck contracture, or other bladder or urethral pathology that could limit catheterization
• •Previous rectal surgery (other than hemorrhoidectomy) or history of rectal disease if the therapy or patient evaluation may potentially cause injury to sites of previous rectal surgery, e.g. if a transrectal probe is used
• •Previous pelvic irradiation or radical pelvic surgery
• •Previous prostate surgery, balloon dilatation, stent implantation, laser prostatectomy, hyperthermia, or any other invasive treatment to the prostate
• •Prior transurethral resection of the prostate or other invasive therapies
• •Coagulation disturbances not normalized by medical treatment
• •Acute urinary retention
• •Hypersensitivity to gelatin products
• •Any contraindication to embolization, including intolerance to vessel occlusion procedures, vascular anatomy/blood flow that precludes catheter placement or embolic agent injection, presence/likely onset of vasospasm, presence/likely onset of hemorrhage, severe atheromatous disease, feeding arteries smaller than distal branches, arteriovenous shunt, and collateral vessel pathways endangering normal territories during embolization or pelvic inflammatory disease